UPDATE: Police have re-opened all lanes.

LIVERMORE (KRON) — According to Police, a major fatal traffic collision happened Wednesday morning at Isabel Ave in Livermore, closing all lanes.

Both North and Southbound lanes are closed on Highway 84 (Isabel Ave.) between Vineyard Ave. and Vallecitos Rd.

As of 3:34 p.m., crews are still trying to upright the big-rig and tow it away. The truck flipped onto its side and the trailer split open, spilling its load of bottled water, police spokeswoman Officer Traci Rebiejo said.

All the bottled water needs to be unloaded before the truck can be moved, Rebiejo said. The road is expected to remain closed until at least 6 p.m.

According to police the accident involved several vehicles and will take hours to clear.  Three people were transported to a local hospital for treatment, and one died on scene.

The crash was reported at 4:46 a.m.

“Early indications are that traffic was slowing, and it kind of came up on him fast and he wasn’t able to slow in time,” police Sgt. Steve Goard said.

A man in one of the cars was pronounced dead at the scene, while the big-rig driver and two other people were taken to the hospital as a precaution because of complaints of pain, Goard said.

Police released a statement saying “Please drive safe and take an alternative route. We will update you when the lanes are re-opened.”

KRON 4 has a reporter headed to the scene for a live report.

Police are advising motorists to seek an alternate route, such as Arroyo Road, around the scene of the crash.

Stay with KRON 4 as more information is made available.